

In the Season 4 finale, after a massive bus accident left House without recollection of the accident, he and the team put the pieces of his memory together and discover Wilson’s girlfriend Amber was on the bus with him and was fatally injured. Wilson has to face the shocking realization that House was involved in Amber’s death. As Season 5 opens, with his friendship with Wilson shattered, House must determine if he’s responsible for Amber’s death and Wilson must decide if House is a destructive force in his life while Cuddy attempts to advance a reconciliation between the two of the
All episodes — Season 5
S5 E1Dying Changes Everything
Sep 16, 20087.944 min
In the aftermath of personal tragedy, Wilson resigns from the hospital... and from his friendship with House. Meanwhile, Thirteen struggles with her personal medical problems while helping treat an executive assistant with a similar situati
S5 E2Not Cancer
Sep 23, 20087.744 min
The team deals with an organ donor whose organs prove fatal, and the two surviving patients. Meanwhile, House hires a private detective to spy on Wilson, but hears a few things about himself that he'd rather not.
S5 E3Adverse Events
Sep 30, 20087.844 min
A painter's undiagnosed illness affects his work, and House and his team must look at the man's paintings to determine what's wrong with him.
S5 E4Birthmarks
Oct 14, 20088.244 min
While en route to his father's funeral, House must help the team with a differential diagnosis on a young Chinese girl who has collapsed under mysterious circumstances.
S5 E5Lucky Thirteen
Oct 21, 20087.644 min
Thirteen brings her one-night stand to the hospital after the woman has a seizure. However, the woman admits she slept with Thirteen just so she could get to House and have him diagnose her condition. Meanwhile, House continues to pay Lucas
S5 E6Joy
Oct 28, 20087.644 min
An ailing man suffers from blackouts and sleepwalks, leading the team to wonder if his sleepwalking is a symptom, or how the man is becoming exposed to something else. When the man's daughter grows ill as well, the team must provide a diagn
S5 E7The Itch
Nov 11, 20087.844 min
The team must treat an agoraphobic who refuses to leave his house, and have to work around Cuddy, who is less than thrilled at having hospital equipment relocated. Meanwhile, House is plagued by an itch, and Cameron and Chase have relations
S5 E8Emancipation
Nov 18, 20087.644 min
While Foreman takes on a pediatric case on his own, the rest of the team deals with a 16-year-old factory manager and emancipated minor who collapses at work. When Foreman's patient takes a turn for the worse, he's forced to question whethe
S5 E9Last Resort
Nov 25, 20088.143 min
A gun-wielding man from the waiting room at the Princeton-Plainsboro clinic takes House, Thirteen and several patients from the waiting room hostage in Cuddy's office. The man claims to be sick with a long undiagnosed illness and demands me
S5 E10Let Them Eat Cake
Dec 2, 20087.844 min
The team takes on the case of a fitness guru on an all-natural diet who collapsed while filming a video. Meanwhile, Foreman conducts Huntington's Disease drug trials and Thirteen signs on as a subject, Cuddy is forced to move into House's o
S5 E11Joy to the World
Dec 9, 20087.944 min
House and his team deal with a bullied girl who collapses during her school's Christmas program. Meanwhile, Foreman and Thirteen grow closer during the Huntington's disease drug trials, House gives a patient a gift, the staff wonder who gav
S5 E12Painless
Jan 19, 20097.744 min
House and the team try to diagnose a man living with severe, chronic pain; Thirteen and Foreman explore their complicated relationship; Cuddy discovers that caring for her baby leaves her with little time to run the hospital.
S5 E13Big Baby
Jan 26, 20097.644 min
Cuddy decides to spend more time at home to take care of her newly adopted baby and passes some of her day-to-day responsibilities off to Cameron, including supervising House. Cameron is forced to play House’s games and becomes involved in
S5 E14The Greater Good
Feb 2, 20097.744 min
House and the team take on the case of a woman who collapsed in the middle of a cooking class, and they soon learn she is a highly-renowned cancer researcher who recently gave up her entire career in order to pursue her own personal happine
S5 E15Unfaithful
Feb 16, 20097.844 min
When a priest who runs a homeless shelter sees a bleeding Jesus hovering at his doorstep, he is admitted to the ER. House takes on the case as a distraction for the team while he confronts Foreman and Thirteen about their relationship. The
S5 E16The Softer Side
Feb 23, 20097.844 min
A patient with both male and female DNA has the team stumped. Meanwhile, House starts acting nicely, raising Cuddy's and Wilson's suspicions that something is terribly wrong.
S5 E17The Social Contract
Mar 9, 20098.344 min
House and the team take on the case of Nick, a book editor who loses his inhibitions. The team realizes Nick has frontal lobe disinhibition, which causes him to speak his mind having no control over what he says and making him just like Hou
S5 E18Here Kitty
Mar 16, 20097.844 min
Morgan works in a nursing home with a pet cat who only sleeps next to people if they are about to die - and does so with alarmingly accuracy. When it seems the cat has predicted her own death, Morgan, convinced she is about to die, fakes a
S5 E19Locked In
Mar 30, 20098.444 min
A man awakens in New York after a bicycle accident unable to move or communicate in any way. House, himself injured in a motorcycle mishap, occupies the hospital bed next to Lee and quickly annoys the doctors treating them both by insisting
S5 E20Simple Explanation
Apr 6, 20097.844 min
Charlotte, an older woman who has spent the last six months taking care of her dying husband Eddie, is rushed to Princeton Plainsboro after collapsing from respiratory failure. The couple becomes a double mystery for the team when Eddie beg
S5 E21Saviors
Apr 13, 20097.844 min
Cameron postpones her vacation with Chase in order to ask House to accept the case of an environmental radical who collapsed at a protest with unexplainable symptoms. Although suspicious of her motives, House agrees. Since she pushed him to
S5 E22House Divided
Apr 27, 20098.444 min
The team takes on the case of a deaf 14-year-old named Seth who collapsed after he started “hearing” explosions while competing in a wrestling match. When the team tries to test him for seizures, Seth loses vision in one eye, complicating H
S5 E23Under My Skin
May 4, 20098.544 min
House and the team take on the case of a ballerina whose lungs collapse in the middle of a performance. When the treatment causes her skin to fall off, the dancer faces not only the prospect of never dancing again but also of dying an agoni
S5 E24Both Sides Now
May 11, 20098.744 min
House and the team are intrigued by Scott, a man whose left brain and right brain operate independently, leaving him with two distinct personalities and no control over some of his actions. As the two sides of Scott’s brain struggle for dom