House and the team take on the case of a woman who collapsed in the middle of a cooking class, and they soon learn she is a highly-renowned cancer researcher who recently gave up her entire career in order to pursue her own personal happiness. Though the team struggles to understand how the woman could give up saving lives for the sake of her own contentment, each grapple with the pursuit of happiness (or lack thereof) in their own lives. As the patient’s condition continues to worsen, so does Thirteen’s as she begins to suffer serious and life-threatening reactions to the experimental Huntington’s Disease clinical trial. Meanwhile, Cuddy attempts to make House’s life miserable for him in retaliation for his part in her own unhappiness.
- Directed by
- Lesli Linka Glatter
- Written by
- Sara Hess
Guest stars
All episodes — Season 5
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S5 E1Dying Changes Everything
Sep 16, 20087.944 min
In the aftermath of personal tragedy, Wilson resigns from the hospital... and from his friendship with House. Meanwhile, Thirteen struggles with her personal medical problems while helping treat an executive assistant with a similar situati
S5 E2Not Cancer
Sep 23, 20087.744 min
The team deals with an organ donor whose organs prove fatal, and the two surviving patients. Meanwhile, House hires a private detective to spy on Wilson, but hears a few things about himself that he'd rather not.
S5 E3Adverse Events
Sep 30, 20087.844 min
A painter's undiagnosed illness affects his work, and House and his team must look at the man's paintings to determine what's wrong with him.
S5 E4Birthmarks
Oct 14, 20088.244 min
While en route to his father's funeral, House must help the team with a differential diagnosis on a young Chinese girl who has collapsed under mysterious circumstances.
S5 E5Lucky Thirteen
Oct 21, 20087.644 min
Thirteen brings her one-night stand to the hospital after the woman has a seizure. However, the woman admits she slept with Thirteen just so she could get to House and have him diagnose her condition. Meanwhile, House continues to pay Lucas
S5 E6Joy
Oct 28, 20087.644 min
An ailing man suffers from blackouts and sleepwalks, leading the team to wonder if his sleepwalking is a symptom, or how the man is becoming exposed to something else. When the man's daughter grows ill as well, the team must provide a diagn





